300905 Lecture Notes - Lecture 60: Tumor Necrosis Factor Superfamily, Regulatory T Cell, Cytokine

• School: UWS
• Department: University of Western Sydney
• Course: 300905
• Professor: anonymous

Document Summary

Psoriasis is characterized by an abnormally excessive and rapid growth of the epidermal layer of the skin. Abnormal production of skin cells especially during wound repair and an overabundance of skin cells result from the sequence of pathological events in psoriasis. 3 5 days in psoriasis rather than the usual 28 30 days. These changes are believed to stem from the premature maturation of keratinocytes induced by an inflammatory cascade in the dermis involving dendritic cells, macrophages, and t cells (three subtypes of white blood cells). These immune cells move from the dermis to the epidermis and secrete inflammatory chemical signals (cytokines) such as interleukin. 36y, tumour necrosis factor-a, interleukin-1b, interleukin-6 and interleukin-22. These secreted inflammatory signals are believed to stimulate keratinocytes to proliferate. One hypothesis is that psoriasis involves a defect in regulatory t cells, and in the regulatory cytokine interleukin-10.