ANHB1102 Lecture Notes - Lecture 3: Nasal Septum, Hypoventilation, Bronchus

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Respiratory System:
Respiration: the exchange of gases between the atmosphere, blood and the cells
Includes
- Movement of air from outside body into lungs (inspiration/expiration)
- Exchange of gases from lungs to blood (external respiration)
- Exchange of gases from blood to cells (internal respiration)
-
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Functions:
Move air into and from body (for O2 and CO2 exchange):
Non respiratory functions
- Provide nonspecific defense
against pathogens
- Homeostasis of body fluids
(especially pH)
- Vocal communication
- Olfaction
Development:
4 weeks:
- buds off foregut endoderm into pleural cavity
- buds continue to grow and branch
5 weeks:
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8 weeks:
- mesoderm forms cartilages,
muscle, connective tissue
supports.
24 weeks:
- alveoli developed sufficiently for
survival
24-28 weeks:
- surfactant production begins
Surfactant production increased in final 2 months
Birth:
- first gasp takes a lot of effort lungs never empty
again
Respiratory mucosa:
Mucous membrane = respiratory epithelium +
underlying connective tissue
- respiratory epithelium = pseudostratified
ciliated columnar with goblet cells
- connective tissue with mucous and serous
glands and blood sinusoids.
Mucosa lines entire tract down to respiratory
bronchioles.
Smoking paralyses the cilia on lining
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Document Summary

Respiration: the exchange of gases between the atmosphere, blood and the cells. Movement of air from outside body into lungs (inspiration/expiration) Exchange of gases from lungs to blood (external respiration) Exchange of gases from blood to cells (internal respiration) Move air into and from body (for o2 and co2 exchange): Buds off foregut endoderm into pleural cavity. Mesoderm forms cartilages, muscle, connective tissue supports. Birth: first gasp takes a lot of effort lungs never empty again. Mucous membrane = respiratory epithelium + underlying connective tissue respiratory epithelium = pseudostratified ciliated columnar with goblet cells connective tissue with mucous and serous glands and blood sinusoids. Mucosa lines entire tract down to respiratory bronchioles. Divided to 2 halves nasal fossae by nasal septum. Lined with simple squamous epithelium and has hairs. Conchae have passage under them called meatus, so air touches the mucous membrane on way through, to pick up dust etc. Allow to warm, cleanse and humidify air.

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