IMED1001 Lecture Notes - Lecture 5: Cell Membrane, Oligodendrocyte, Schwann Cell
Document Summary
Know the ionic composition of ecf and icf. Describe and explain the ionic basis of electrical signalling in nerve and muscle cells (action potentials) Describe how action potentials are propagated along membranes. Luigi galvani in around 1785 dissected a frog while standing near a static generator- touch made the frog"s leg twitch. Electrostimulation of decreased limbs (performed on the executed criminal george foster) Complete distribution of ions- will not diffuse across membrane unless the membrane lets then(until ion channel opens)- to change the distribution of ions across the plasma membrane. All the cells have a huge concentration gradient where sodium wants to get in and k wants to get out so if their respective channels open. Change the positive and negative electrical balance across the membrane. If sodium ion channel opens- flood inside the cell- hence charge. Diffusion of ions is determined by: membrane permeability, concentration gradient, voltage gradient. Inside of chell is negagvive, outside of cell is.