PHAR2210 Lecture Notes - Lecture 11: G Protein–Coupled Receptor, Post-Translational Modification, Sh2 Domain
Document Summary
Phosphorylation- associated with kinase added phosphates resulting in the activation of protein: dephosphorylation- associated with dephosphorylation removed phosphates resulting in the deactivation of protein. Phosphorylation is the most common type of post- translational modification. 3 amino acids can be phosphorylated by kinase: Targets for phosphorylation: wide range of targets, receptors. Ion channels: transporters, enzymes, results in change in protein function/activity/ expression. G protein mediated signalling: the receptor arrestin complex serves as a scaffold to facilitate signalling pathways (arrestin is also capable of facilitating signalling pathways independent of. Kinase cascades: ligand: dimer: when a ligand binds to 2 monomers, and will undergo dimerization, hence forming homodimer. Main groups of kinase-linked receptors: receptor tyrosine kinase, e. g. growth factors, insulin and igf (insulin like growth factor, receptor serine/threonine kinase, e. g. transforming growth factor (tgf) . Cytokine receptor: e. g. interleukins and interferons, receptor guanylate cyclase, e. g. natriuretic peptides, ras/raf/mapk: receptor tyrosine kinase with. Ligand binds to the rtk: rtk dimerize.
