BIOL 2021 Lecture Notes - Lecture 13: Osmotic Concentration, Phosphoinositide 3-Kinase, Membrane Transport Protein
1 Mar 2017
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Fig 15-41 cascade that cause an amplification signal: one photon can end up producitn many molecules being hydrolyzed, then changing membrane potential. Quesiton: gpcr and enzyme coupled receptors often activate some of the same signaling pathways, why do some extracellular signals use one kind of receptor rather than another: a: we don"t know. Receptor tyrosine kinase (rtk: phosphorylate proteins on tyrosines, so these are not ser/thr kinases. Couple the rtk to some other protein. Fig 15-8 molecular switch of the monomeric gtpase active = gtp bound inactive = gdp bound. Fig 15-47 rtk activates ras: turning on the signal. Adaptor protein binds (don"t need to know their names) This catalyzes the exchange of gdp for gtp. Ways to create signaling complexes fig 15-50 map kinase modules in yeast: note: not just activated by rtks or ras proteins. Mating factors give you a mating response.
