PHAR2210 Lecture Notes - Lecture 15: Superoxide Dismutase, Xenobiotic, Congenital Disorder
Document Summary
Developmental defects produced by equivalent doses of a teratogen administered on different days of prenatal. Unborn: development in rats: developmental toxicity: toxicity toward the unborn during prenatal development can be reversible or irreversible, affects unborn at doses that aren"t toxic to the mother. Embryolethality: chemical toxicity incompatible with embryo survival results in resorption, spontaneous abortion, or stillbirth. Teratogenicity: induction of irreversible structural alterations but not embryolethality can reflect either parental exposure prior to conception or maternal exposure during pregnancy. Teratology = the scientific study of birth abnormalities. Some factors influence the susceptibility of the unborn to developmental toxicants: Timing of exposure: the type and severity of toxicity depends strongly on the timing of exposure (cf. other types of toxic responses) Lipophilic compounds with a mw < 500-600 can cross: weak acids readily accumulate, blood flow rate-determining ( with foetal size, transplacental drug transfer via diffusion and drug transporters.
