EHR522 Lecture Notes - Lecture 1: Gestational Diabetes, Dialysis, Glut4
Document Summary
Week 1: metabolic conditions focus: insulin sensitivity and glucose transport. 1. 05 million people with type 2 diabetes (t2d) 4,400 amputations of toes, feet or limbs. The pancreas and its functions: one of the main digestive organs, secretes two important hormones: Insulin and glucagon: two major tissue types: Three cell types: alpha, secretes glucagon. Insulin and glucagon are released to regulate blood glucose levels. When glucose concentrations too high (hyperglycaemia) insulin released to bring blood glucose back within range. If blood glucose falls too low (hypoglycaemia), glucagon is released to break down stored glucose. Damage to many tissues especially blood vessels. Insulin signalling: refers to the cascade of events that cause the translocation of. Glut"s from an inactive depot in the cell cytosol to the cell surface allowing admission of glucose stimulated by insulin. Insulin receptor process: secreted into blood in unbound form, activation of target cells: Binds with and then activates insulin receptor.
