HSE201 Lecture Notes - Lecture 8: Adenylate Kinase, Oxidizing Agent, Creatine Kinase
22 Oct 2018
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Summarised chapters 3 & 4: bioenergetics and exercise metabolism. There are two subpopulations of mitochondria within skeletal fibres: subsarcolemmal mitochondria that are located directly beneath the cell membrane (sarcolemma) produce energy required to maintain active transport of ions across the sarcolemma. Intermyofibrillar mitochondria that are found near the myofibrillar (contractile) proteins provide the energy to sustain muscle contraction. Coupled reactions are linked so that the energy released by one fuels another. Oxidation is the process of removing an electron and reduction is the process of adding an electron. The reducing agent donates an electron, where as the oxidising agent takes an electron. Two molecules that play a role in donating electrons are: Flavin adenine dinucleotide (from riboflavin) fad is the oxidised form (electron removed) Atp: the ratio of atp:adp generally stays constant in a cell, due to the enzyme adenylate kinase, which forms atp and amp ut of two adp molecules.
