BCMB30004 Lecture Notes - Lecture 35: L-Dopa, Synuclein, Mptp

• School: University of Melbourne
• Department: Biochemistry and Molecular Biology
• Course: BCMB30004
• Professor: Professor Cheng

Document Summary

* parki(cid:374)so(cid:374)"s disease is due to pre(cid:373)ature death of a regio(cid:374) of (cid:271)rai(cid:374) (cid:272)ells i(cid:374) a regio(cid:374) of the (cid:271)rai(cid:374) called the substantia nigra pars compacta and this particular group of neurons secretes dopamine. * left pic = the nigrostriatal pathway: most of the pathway will fit into the thalamus area and then from there they fit into the motor cortex which controls our body movements. * right pic = a lot of them go into the basal ganglia which is a cluster of neurons and from there they send out signals and the signals are being sent to the motor cortex. * the pic shows all the basal ganglia to which the nigrostriatal dopaminergic neurons impinge upon and then from the basal ganglia they integrate all the signals and send it to the motor cortex to regulate our bodily movement.