BIOM20001 Lecture Notes - Lecture 65: Epithelium, Endothelium, Fibroblast
Document Summary
Display antigens to t-lymphocytes and respond to signals from t cells. Die or (cid:858)(cid:449)a(cid:374)der off(cid:859) i(cid:374) the a(cid:271)se(cid:374)(cid:272)e of i(cid:374)fla(cid:373)(cid:373)atory sti(cid:373)ulus. M1 classical activation by microbial products/peptides and ifn- . M2 alternative activation by other cytokines (il-4, il-5 and il-13) Mobilized by immune stimulus (infection) and non-immune mediated inflammation. B-lymphocytes develop into plasma cells and secrete antibodies. Defense against helminthic parasites and allergic inflammation (asthma) Granules release major basic protein (toxic to parasites and causes epithelial cell necrosis) Early vascular change in acute inflammation (histamine, leukotrienes) Although a hallmark of acute inflammation, may be present in some forms of chronic inflammation. Chronic ulcer: e. g. ulcer in stomach due to acid. Fibrosis (myofibroblasts) pull the folds of the stomach to the ulcer. Chronic abscess cavity: healing is the scarred (fibrosis) outline around the abscess. Thickening and scarring of the wall of viscus (e. g. gall bladder wall, caused by gall stones) Diffuse inflammation (all the features of chronic inflammation without granulomas)
