PSYC20006 Lecture Notes - Fall 2017 Lecture 6 - Free recall, Spatial disorientation, Muscle tone

• School: University of Melbourne
• Department: Psychology
• Course: PSYC20006
• Professor: Stefan Bode

Document Summary

Intensity of neuropathological features correlates closely with severity of dementia: course of neuropathological changes (amnestic) Commence in the hippocampus (medial temporal lobe) Spread to involve frontal cortex (last to be involved) Spread posteriorly to the parietal cortex: clinical pattern of dementia of the alzheimer type. Initially see mtl memory impairment die to early predominance of hippocampal/mtl involvement. Anterograde memory impaired new learning; impaired delayed recall; poor recognition memory. Retrograde memory intact for remote memories; reduced for recent retrograde memories. Wernicke-type aphasia due to spread into posterior temporal lobe word-finding difficulties (inability to remember nouns); fluent (grammatical speech) Visuospatial deficits and topographical disorientation due to spread into parietal lobes dyspraxia, agnosia and acalculia. Behavioural changes due to spread of disease into frontal lobes (most common apathy; agitation) Eventually the disease affects all of the neocortex and generalised impairments in all domains can be seen.