Anatomy and Cell Biology 4429A Lecture Notes - Lecture 7: Amyloid Precursor Protein Secretase, Cell Adhesion, Presenilin

• School: Western University
• Department: Anatomy and Cell Biology
• Course: Anatomy and Cell Biology 4429A
• Professor: Paul Walton

Document Summary

There are two major problems of this test: Not very good at detecting the early stages of the disease since the scores determining mild/moderate/severe is not very far apart. It"s a (cid:373)easu(cid:396)e fo(cid:396) (cid:272)og(cid:374)iti(cid:448)e fu(cid:374)(cid:272)tio(cid:374); (cid:374)ot (cid:396)eally the disease itself so people who have dyslexia or other problems may score low as well. Diagnosis relies on neuropathological examination post mortem: senile or amyloid plaques: Product of the amyloid precursor protein (app), identified in 1987. Surrounded by dystrophic neurites, reactive astrocytes, and microglia: neurofibrillary tangles (nft): twisted fibers that build up inside the nerve cell. Darkly staining masses of abnormal filaments 8-20 nm width and. 80 nm long fibers paired helical filament (phf) App gene (amyloid precursor protein), chromosome 21. *high a(cid:373)ou(cid:374)ts i(cid:374)(cid:272)(cid:396)ease the (cid:396)isk of de(cid:448)elopi(cid:374)g alzhei(cid:373)e(cid:396)"s. *gly(cid:272)olipids i(cid:374) (cid:374)eu(cid:396)o(cid:374)s te(cid:374)d to i(cid:374)(cid:272)(cid:396)ease i(cid:374) alzhei(cid:373)e(cid:396)"s the simple ones increase and the complex forms decrease (caughlin, s. et al.