IMM2011 Lecture Notes - Lecture 12: Mycobacterium Tuberculosis, Antibody, Cell-Mediated Immunity
23 Jun 2018
School
Department
Course
Professor
T CELL .
Recap:
What is MHC:
Major histocompatibility complex
Dendritic cell: only professional APC that can activate naive T cell.
three types of antigen presenting cell :macrophages b cell and dendritic
cell. only dendritic cell will activate naive t cell other will activate effector
cell or memory cell
- DC found in tissue
- Lymph node: exposure to pathogen causes them to be activated.
when pattern recognition receptor dc recognizes pathogen on
receptor cell- will be activated
- immature: highly phagocytic(low mhc expression, low co
stimulation molecular and mature are not phagocytic(high MHC)
and high co stimulatory molecule
- migrates and goes to t cell zone, by cytokine and chemokines.
- present peptide antigen to the t cell and activate the t cell.
Function:
Present peptide antigen to T cell.
T CELL IMMUNE RESPONSE:
• List and describe the properties
of adaptive immunity
- Deals with any pathogens
effectively
- Each lymphocytes is specific
and respond to one antigen only.
- different specificities ( ~109 for BCR and ~1011 for TCR) - these
can recognise billions of antigens!
- Which are generated through Somatic recombination (V(D)J
combinatorial diversity and junctional diversity)
Clonal selection theory:
framework of adaptive immune response.
Lymphocytes population have clones which rises from a precursor.
- Each clone has antigen receptors for a single specificity
- Through somatic combination different antigen receptors
generated .
- Following exposure to pathogen- clone is selected and expands in
numbers to allow for antigen specific immune response.
Comparing adaptive to innate immune response:
Specificity : innate immune response is more broadly specific in one
innate immune cells has many pattern recognition receptor cell through
which can recognize certain pathogen associated molecular pattern
recognition.
- while adaptive immune response is more specific in which one
antigen is recognized by each lymphocytes.
Diversity: diversity of B lymphocytes is through somatic recombination
which is from genetic and on the other hand innate immune cells have
limited diversity for the PRR and this is germline encoded.
Memory: adaptive immune response stores memory of the pathogen
through specifc Ig antibodies which will find a home in the bone marrow
to burrow. While innate immune response respond the same way each
time despite multiple encounters with the same antigen as it does not
store memory.
Conal expansion: adaptive immune response displays this property in
which increased number of antigen specific lymphocytes from a small
number of naive lymphocytes when that specific clone is chosen . While
Document Summary
Dendritic cell: only professional apc that can activate naive t cell. three types of antigen presenting cell :macrophages b cell and dendritic cell. only dendritic cell will activate naive t cell other will activate effector cell or memory cell. Migrates and goes to t cell zone, by cytokine and chemokines. Present peptide antigen to the t cell and activate the t cell. T cell immune response: list and describe the properties of adaptive immunity. Each lymphocytes is specific and respond to one antigen only. Different specificities ( ~109 for bcr and ~1011 for tcr) - these can recognise billions of antigens! Which are generated through somatic recombination (v(d)j combinatorial diversity and junctional diversity) Clonal selection theory : framework of adaptive immune response. Lymphocytes population have clones which rises from a precursor. Each clone has antigen receptors for a single specificity. Through somatic combination different antigen receptors generated .
