PHA3801 Lecture Notes - Lecture 9: Area Postrema, Maleic Acid, Ionic Bonding
24 Jul 2018
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Ap in nerve terminal opens ca channels ca entry causes vesicle fusion w membrane and transmitter release (into synaptic cleft) receptor-channels open, na enters the post-synaptic cells and vesicles recycle. An axon can make contact anywhere along the 2nd neuron; on the dendrites (axodendritic synapse), the cell body (axosomatic synapse), or the axons (axoaxonal synapse). Nerve impulses are transmitted at synapses by the release of neurotransmitters. Cns synapses usually have a small number of release sites, while nerve muscle synapses have up to 300 active zones. Neurotransmitters: synthesis is in the neuron, storage of nt or precursor is in the pre-synaptic nerve terminal (usually in vesicles). The released nt into the synaptic cleft binds to target receptors. There is a mechanism in place to remove transmitter from synaptic cleft. Nt is synthesized in cell body or in terminal (biosynthetic enzymes) nt packaged into vesicles .
