PHAR2220 Lecture Notes - Lecture 8: Plastination, Cell Culture, Design Of Experiments
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Document Summary
Plastination: o method of preserving perishable biological specimens by replacing the tissue water and lipid with a plastic polymer o plastinated specimens retain textures and structures of tissue and may be used in teaching and learning. Dr scott reuben, american anaesthesiologist, pain o did not conduct 21 published clinical trials (2000s) o no ethics approval for studies o presented fabricated results of trials o non opioid medications were as effective as opiates for the management of post operative pain o opiates are addictive and have adverse side effects o post operative healing slowed as practice was changed. In 1996, occasional reports of paradoxical bronchospasm" o glaxosmithkline conducted a randomised trial to compare patients on salmeterol vs placebo o primary outcome was respiratory deaths and life threatening experiences o 60,000 patients, 28 week close monitoring, then 6 months o 26,000 patients were recruited by 2002.
