BIOL 2P97 Lecture Notes - Lecture 10: Bloating, Trypsin, Carboxypeptidase
24 Aug 2015
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Lecture 3 - gastrointestinal physiology: digestion/absorption of proteins and fats, digestion/absorption of various nutrients, locations of absorption of various nutrients. Lactose intolerance: deficiency of lactase leads to, undigested lactose, it cannot be absorbed as a disaccharide, water gets drawn into the lumen of the intestine in an attempt to dilute it. Can lead to diarrhea: lactose enters the large intestine, bacteria that live in the large intestine start to break down the lactose, causing fermentation, leads to bloating, abdominal pain, and discomfort. Digestion and absorption of proteins: enzymes for protein digestion are classified two groups, endopeptidases, exopeptidases. Break long peptide chains into smaller ones. Break single amino acids off from the ends of the peptide. Endopeptidases: commonly referred to as proteases, examples, pepsin (stomach, trypsin/chymotrypsin (pancreas) Exopeptidases: aminopeptidase: releases amino acid from the amino terminal end, carboxypeptidase: releases amino acid from the carboxy-terminal end. This is by far the more important of the two exopeptidases.
