SCIE 1P51 Lecture Notes - Lecture 18: Food Additive, Mayonnaise, Lecithin
16 Sep 2016
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Keep oil and water based ingredients homogenised/mixed mayonnaise, peanut butter, etc. No food additive can be used without safety assessment and approval. Adi acceptable daily intake: the amount of a food additive, expressed on a body weight basis, that can be ingested daily over a lifetime without appreciable health risk. Effects of enzymes and gut flora on compound. Amount of chemical that kills exactly half of the population of animals. Ld50 is expressed as weight of substance per unit weight of test animal: toxicity testing, method of adminstration. Orally subcutaneously (injected under skin) intrapentoneally (stomach) intravenously (bloodstream: problem with lethal dose = cruel, levels determined in this phase used for next level of testing, pharmaceuticals/food additives. Ld50 = smaller the number, more toxic the compound is. 10g/kg: short term toxicity, dose refinement, identify target organs, two species rats & dogs, various dose levels, controlled (placebo used, 28 days continous exposure, animals euthanized after, sub-chronic toxicity, determine noael.
