NEUR 3302 Lecture Notes - Lecture 4: Aromatase, Castration, Prefrontal Cortex
7 Oct 2016
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Estrogens have 3 different receptors: era (alpha receptor) nuclear receptor, erb (beta receptor) nuclear receptor. Nuclear receptor- steroid hormone receptors in cytoplasm. **you need these changes in protein production before estrogen elicits their effects. Can also be found in the membrane too. Rapid effects by activating glutamate receptors: gper1. G-protein coupled receptor: binding to these receptors is how estrogen has effects. There are interactions between estrogens and dopamine: estrogens increase dopamine transmission in many ways, medial hypothalamus. Generally a slow response because there are mostly nuclear receptors in that area: staitum. E2 slow and rapid increase in dopamine availability. E2 maintains levels of d1 and d2 receptors and maintains these binding sites: nac. And e2 maintains levels of d1 and d2 receptors. The way test has effects is by being converted into estrodial which allows it to have effects on dopamine transmission and sexual behaviors. Testosterone also seems to increase dopamine transmission: medial hypo.
