PSYC 3403 Lecture Notes - Lecture 2: Acetylcholine, Ibuprofen, Monoamine Oxidase

• School: Carleton University
• Department: Psychology
• Course: PSYC 3403
• Professor: Tarry Ahuja

Document Summary

Receptors (characteristics: membrane-spanning protein, binding sites for endogenous neurotransmitters and drug molecules, composed of 7 or 12 alpha helical coils. There is a (cid:498)sweet spot(cid:499) on receptors that neurotransmitters attach to. It is attracted by a charge: coils make up a segment, the segment joins other segments and makes a channel, neurotransmitters and drugs bind within tm coils held by ionic forces. Receptors (characteristics: reversible binding activates receptor causing conformational change. Intensity of signal determined b number of percentage of drug-receptor interaction. If you have more (cid:498)keys(cid:499) you can let ions in even faster: neurotransmitters and drugs interact with binding site on receptor or to a nearby site. You can have a receptor away from the channel, it"s like a handicap button that opens a door to the school. Initiate cellular response similar or identical to that of neurotransmitter (agonist). The drug does the same thing as an neurotransmitter: binding to a nearby site which facilitates a neurotransmitter binding (agonist).