BIOL 366 Lecture Notes - Lecture 9: Cerebrospinal Fluid, Neural Stem Cell, Growth Differentiation Factor
12 Feb 2018
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Document Summary
The v-svz (ventricular-subventricular zone)contains numerous cell types and responds to multiple stimuli (e. g. , cerebrospinal fluid, blood, neuronal stimulation) Vcam1 > adherence to the rosette niche. Oscillating levels of notch and hes cause bursts of proliferation (high n > quiescence) Only the nsc of v-svz maintains contact with the cerebral spinal fluid. During the development of adult v-svz, radial glia-like nsc transition into type b cells that fuel. There is continued neurogenesis throughout life the generation of specific types of neurons. B cells project a primary cilium from their apical surface into the cerebrospinal fluid of the ventricular space, and a long basal process terminates with an endfoot tightly contacting blood vessels. Fundamental cell constituents of the v-svz niche include 4 cell types (1) a layer of ependymal cells, e-cells, along the ventricular wall (2) the neural stem cell (b cell) (3) progenitor (transit-amplifying) c cells (4) migrating neuroblast a cells.
