BIOL 461 Lecture Notes - Lecture 22: Petal, Model Organism, Gynoecium
24 Apr 2018
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Biol 461 lecture 22 week 12 friday 06/04/2018. The order in which her-1 and tra-1 act in sex determination in c elegans. Mutant phenotypes occur in the opposite signal state (in terms of x:autosome ratio) and tra1 is epistatic to her1, and when you have signals in the opposite signal state that means that the interaction is negative (repressive) When you make the double mutant, you get the phenotype of tra-1. In a negative hierarchy, the epistatic gene is. Si(cid:374)(cid:272)e it"s a (cid:374)egati(cid:448)e hie(cid:396)a(cid:396)(cid:272)h(cid:455), the epistati(cid:272) ge(cid:374)e is downstream (which is tra-1) Her-1 mutant is upstream and if you lose her-1 function, tra-1 will be automatically on in response to the xo. Normally xo turns her-1 on, which turns off tra-1 which makes a male. If you have 2 x (ratio of 1): her-1 is off, tra1 is on, you get a hermaphrodite. Does(cid:374)"t (cid:373)atte(cid:396) (cid:449)hethe(cid:396) her-1 is there to turn it off or not, its off because its mutant.
