CHEM 271 Lecture Notes - Lecture 5: Carboxyhemoglobin, Cooperative Binding, Protoporphyrin Ix
13 Dec 2016
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You should know what the biological functions are of myoglobin and hemoglobin. Hemoglobin also carries co2 to the lungs. You should know about the properties of heme in myoglobin and hemoglobin (you do not need to memorize the structure) Consists of an organic compound called protoporphyrin and an fe atom. The protoporphyrin is made up of 4 pyrrole rings linked by methane bridges to form a tetrapyrrole ring. You should know what the following refers to: metmyoglobin, deoxyhemoglobin, oxyhemoglobin, carboxyhemoglobin. Deoxyhemoglobin: no o2 binded, t state (tense state) Oxyhemoglobin: 02 binded, r state (relaxed state) Metmyoglobin: when 02 releases as a superoxide instead of a dioxide, leaving the iron in a ferric state (+3) Carboxyhemoglobin: when co binds (same site as oxygen) You should know what the quaternary structure of hemoglobin is. You should know what oxygen-binding curves are, and how to interpret them. Plot of saturation of oxygen against partial pressure of oxygen.
