PSYC 455 Lecture Notes - Lecture 6: Receptor Antagonist, Celecoxib, Inverse Agonist
17 Feb 2018
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Lecture 6 dose-response curves: research papers, instructions, 2 pages, pick a drug (that affects brain behavior): Do all the resear(cid:272)h of e(cid:448)erythi(cid:374)g (cid:449)e"(cid:448)e lear(cid:374)t up to this poi(cid:374)t: Cite: resources, drugbank. com, from last class, saturation binding curve, clarifications: Bmax is found on the y-axis (i. e. it is not a concentration). Kd is 50% of the bmax and it is the number on the x-axis: example: Subtract both to get your specific binding curve: Kd is found on the x-axis: graded dose response curve, example (drug a vs. drug b): More potency (i. e. smaller ec50; reaches its maximal effect at a lower dose, so a better drug at lower doses): quantal dose response curve, looking across populations on a single measure, graph: Y = % population where drug had an effect (based on x; i. e. the dose of the drug). X = doses of drug: ed50 (effective dose 50):
