BIOC 4403 Lecture Notes - Lecture 4: Protein Kinase, Polypyrimidine Tract, Neural Development
23 Mar 2017
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Document Summary
Alternative splicing produces different mrna isoforms from the same gene. Exon skipping is the most common form of alternative splicing in mammals. Intron retention is the most common in yeasts. Splicing pattern of a gene can be disturbed by mutations that change the identity or. The new pattern can become fixed in a species depending on many factors, such as its phenotypic effect, population structure and dynamics. Two mechanisms by which a constitutive exon can become an alternative exon: mutations that lead to suboptimal recognition of the exon and result in exon skipping. Mutations can lead to a new alternative 5" or 3"ss. Mutations can lead to suboptimal recognition of th 5"ss. Mutations in exons can disrupt an exonic splicing enhancer (ese) (or ise) or may create an exonic splicing silencer (ess) (or. Iss) elements in opposite orientation, can interrupt exon recognition. A secondary structure, usually formed between 2 alu.
