BIOL 2020 Lecture Notes - Lecture 22: Microtubule Nucleation, Pericentriolar Material, Centrosome

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18 Mar 2018
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Centrosomes: two perpendicular centrioles (each made of nine triplet microtubules) and pericentriolar material (pcm, pcm a diffuse granular matrix surrounding the centrioles, centrioles seem to recruit pcm to the centrosome, which then nucleates growth of microtubules. For microtubule growth/shrinkage (remember the gtp thing: growth only occurs on the -end (not at the -end, beta end is the building end. Mfs: keratins: tethered to the nuclear envelope and the outer edge of the cell, desmosomes and hemidesmosomes, keratin mutations can lead to cell adherence disorders, ex. Nuclear lamina: thin, dense meshwork of fibers that lines the inner surface of the inner nuclear membrane and helps support the nuclear envelope, lamins are ifs. Smallest fibres (6-8 nm), made of actin protein. Flexible, inextensible helical filament: as a contractile element a microfilament can generate tension. Important for movement in cell and cell itself. Functions: cell shape (cortex: thin region below pm, cell migration, transport of vesicles and organelles (especially plants, cytokinesis, muscle contraction.

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