BIOL 2020 Lecture Notes - Lecture 8: Molecular Motor, Kinetochore, Separase

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During m-phase all energy of the cell is devoted to mitosis. There is no response to external stimuli. The duplicated chromosomes are prepared for segregation and the mitotic machinery is assembled. The chromosomes condense with the help of the activated condensing. The cytoskeleton is disassembled and the mitotic spindle is assembled. Chromosomal microtubules attach to kinetochores of chromosomes. The chromosomes are moved to the spindle equator by the process of congression. The chromosomes are aligned along the metaphase plate and are attached by chromosomal microtubules to both poles. All chromosomes must be attached and under tension for mitosis to continue. Anaphase a and b can happen one after the other or at the same time. * mitotic movements result from both changes in spindle fibre length and from the action of molecular motors. Kinesis-like proteins cenp-e/kinesin 7 (+ end motor) and cytoplasmic dynein (- end motor) position laterally positioned chromosomes.

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