BIOL 2020 Lecture Notes - Lecture 5: Importin, Nuclear Membrane, Nuclear Pore
31 Aug 2016
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Note: all the new proteins are synthesized before mitosis happens and nuclei are not needed. Nuclear envelope bi-layer to allow access to nucleus. Nuclear pore structure that allows molecules to pass through the envelope to the nucleus. Nucleolus full of dna and rna that will be made into ribosomal rna (rrna) Nuclear lamina provides mechanical support to the nuclear envelop. Nuclear pore complex (npc) how proteins get in and out of the cell. Nucleoporins - about 30 different proteins in the npc; each is present in multiple copies (8,16,32) and keeps with the octagonal symmetry of the structure. Proline (p) - hydrophobic traits, but creates kinks in polypeptide chains (disrupt ordered secondary structure) Recognized by importins protein = has alpha and beta subunits (alpha recognizes signal: known as the transporter receptor. Protein wants to leave has another signal recognized by exportins.
