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Drugs for Systemic Fungal Infections.docx

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Department
Nursing
Course
NURS 2050
Professor
Cynthia Barkhouse Mckeen
Semester
Fall

Description
Drugs for Systemic Fungal Infections Polyene Azole Conjugated double bonds, broad spectrum, All are toxic!! Have an azole ring, broad spectrum MOA: binds competitively to ergosterol (in fungal CM, not humans), MOA: Azoles inhibit the conversion of lanosterol to ergosterol (which ↑ perm/ leakage of K = cell death (also toxic to us b/c it binds to sterolis needed in the CM). Without ergosterol, there is ↓ membrane fluidity, in ours, but it binds better to ergosterol). ↑ permeability/leakage of K, inhibited cell growth/replication 1. Amphotericin B: Amphoterrible! **only for toxic fungals 1. Imidazoles: topical infections, tinea Broad spectrum Ketoconazole: needs acidic environment (least desirable) IV only Side effects: Side effects: 1. Infusion RX: phlebitis, fever, chills, edema 1. Impotence, ↓ libido 2. Nephrotoxic: IN ALL PATIENTS, dose dependent 2. Gynecomastia (sterols are similar to hormones) 3. Bone marrow suppression 3. Toxicity to humans (affects the cholesterol) Drug interactions:
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