PATH 3000 Lecture Notes - Lecture 19: Leydig Cell Tumour, Male Reproductive System, Vas Deferens

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Path 3000 lecture 19 march 2, 2020 male reproductive system pathology. Normal male reproductive system: the male reproductive system comprises the testes, epididymis and vas deferens, seminal vesicles, prostate and penis. The testes, the male gonad, has endocrine functions. In the stroma tissues, there are groups of large pink eosinophilic leydig cells, which are sensitive to hormone from the pituitary and makes androgens (male hormones). There are two types of pituitary hormones, fsh and lh. Fsh will work together with testosterone to stimulate spermatogenesis. Lh stimulates leydig cells to secrete androgens, which have a negative feedback to hypothalamus to maintain a normal level of androgens and testosterone being synthesized. Cryptorchidism (congenital malpositioning of testis outside of their normal scrotal location) Infertility can result if both testes are cryptorchid. Cryptochid testes have a 10-fold greater risk of undergoing malignant transformation than do normal testes. During pregnancy, the gonad migrates downwards when the baby reaches the 3rd month of gestation.

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