PHAC 4001 Lecture Notes - Lecture 14: Cyp3A4, Alcohol Dehydrogenase, Alcohol Dependence
12 May 2021
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Phac 4001 lecture 14 february 12, 2021 alcohol i. Canadian centre on substance use and addiction 2017. In canada, there were around 77,000 hospitalizations entirely caused by alcohol in 2015 2016, compared to 75,000 hospitalizations for heart attacks in the same year. In 2002, alcohol was responsible for 4,258 deaths in canada, representing 1. 9% of all deaths. Effects of alcohol use: short term: intoxication, memory loss and blackouts, injury, violence, accidents, spousal abuse, suicide, alcohol toxicity (overdose), death. This is the general pathway of ethanol metabolism. Ethanol is converted into acetaldehyde usually done through alcohol dehydrogenase, which is highly abundant in the liver and in the tissue. Alcohol dehydrogenase uses the reducing power of nad+ to remove a h+ from ethanol (or oxidize ethanol into acetaldehyde). Acetaldehyde is then converted into acetate by aldehyde dehydrogenase. Again, nad+ is the reducing agent that allows for the oxidation to occur.
