BIOL 112 Lecture Notes - Lecture 13: Spindle Apparatus, Homologous Chromosome, Kinetochore

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4 Apr 2016

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So to review: cells have to divide up their contents so that each daughter cell has everything it needs to survive. In the case of the chromosomes, this is an exacting task because you have to get exactly one copy of each chromosome (including one copy of each of the two homologous chromosomes) into each daughter cell. The first thing the cell has to do is make sure that it duplicates the dna once before it divides. It does this by having a ordered series of steps, the cell cycle, controlled by checkpoints that make sure the cell is ready to move on to the next step. The answer is a process that you can (and hopefully will) watch called mitosis. It seems rather complicated when you first study it but, considering the difficult task of dividing up the chromosomes that mitosis must accomplish, it is extraordinarily elegant. These are some events you need to know:

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Some cancer drugs such as vinblastine function by preventingformation of the mitotic spindle. The outcome is to_____________________________ of(in) cancerous cells.
A) prevent chromosomes coiling ready for duplication
B) reinstate the stop/start controls in the cell cycle
C) prevent chromosomes from producing chromatids
D) prevent homologous chromosomes lining up on the metaphaseplate
2. Most of the cell cycle is spent in ________________ during whichtime the cell grows and performs normal functions.
A) interphase
B) S phase
C) G2 phase
D) M (mitotic) phase
3. When an organism is described as âhaploidâ this infers that itscells
A) each contain one set of chromosomes
B) each contain half a chromosome
C) each contain two sets of chromosomes
D) each contain an âYâ chromosome
4. During _________________ of meiosis chromatids of homologouschromosomes exchange genetic material.
A) prophase II
B) anaphase I
C) prophase I
D) anaphase II
5. In a cell containing 20 chromosomes the process of meiosis willresult in ___ chromosomes in each cell.
A) 10
B) 20
C) 40
D) 30
6. Some fungi cells complete mitosis however they do not completecytokinesis. This would result in
A) large nuclei containing many chromatids
B) large cells containing lots of nuclei
C) many cells each containing one nucleus
D) daughter cells identical to the original cell
7. Which of the following statements best describes a karyotype? Apicture showing
A) most pairs of homologous chromosomes including sex chromosomestaken from a skin cell
B) pairs of homologous chromosomes taken from a sperm cell
C) all pairs of homologous chromosomes taken from a skin cell
D) pairs of homologous chromosomes taken from an egg cell
8. Which one of the following occurs during mitosis?
A) Chromosomes are duplicated
B) The cell grows
C) Organelles such as mitochondria are duplicated
D) Chromatids separate
9. The function of meiosis is to generate cells
A) that are identical to the original cell
B) to be used for asexual reproduction
C) to be used in sexual reproduction
D) to be used for tissue repair
10. The general body cells of a Koala bear contain 16 chromosomes.Completion of one cell cycle will result in ______ cell(s) (each)with _____ chromosomes.
A) one; 16
B) two; 32
C) two; 32
D) two; 16

blushsnail26

1)What experiment was performed that allowed for scientists to finally agree that DNA is the genetic material within living organisms?

a.Understand the materials and scientific techniques used to come to this result.

2)What group of experiments led to the discovery of the mechanism used in DNA replication?

a.Understand the materials and scientific techniques used to come to this result.

i.What is a cesium chloride gradient?

ii.Where do 14N and 15N respectively fall along this gradient?

b.The results revealed that DNA replicates using which of the three proposed models?

i. Describe the mechanism of each model.

3)What is the role of the following proteins in DNA replication?

a.Helicase

b.Single strand binding proteins

c.Topoisomerase

d.DNA polymerase III

e.DNA polymerase I

f.Primase

g.Ligase

4)What extra steps are taken to be sure the lagging strand does not shorten each time DNA is replicated?

a.What is the role of telomerase in these âstepsâ?

5)In DNA repair, which enzyme has âproof-readingâ capabilities?

1)Which type of cells within our bodies use mitosis to reproduce?

2)Does mitosis create a cell that is different or the same as the parent cell undergoing division?

3)Describe the DNA found in sister chromatids.

4)Describe the DNA found in homologous chromosomes.

5)What occurs during the following stages of the cell cycle?

a.G₁ Phase

b.S Phase

c.G₂ Phase

d.M Phase

What are the phases of mitosis? What events occur in each phase?

1)Does mitosis separate homologous chromosomes, sister chromatids, or both?

2)What is cytokinesis?

a.Which fibers of the cytoskeleton contract to pinch parent and daughter cells apart from one another in animals?

b.How do microtubules move chromosomes to the two poles of a dividing cell?

3)How are centrioles involved in this process?

a.How do plants form two complete cells during cytokinesis?

4)How do bacterial cells reproduce?

5)The cell cycle is controlled at âcheckpointsâ. What occurs at each of the following checkpoints?

a.G₁ Checkpoint

b.G₂ Checkpoint

c.M Checkpoint

6)How do cyclin and cdk act to control the G2 checkpoint?

7)If presented with the schematic of the M checkpoint, you should be able to explain perturbations to the system as well as if the cell will divide or stall at metaphase.

8)Cancerous cells form when the cell cycle checkpoints do not function correctly and continues to divide even though it is damaged in some way. How does the protein p53 function to keep these cells from dividing?

9)Normal cells follow certain rules of growth that cancerous cells do not follow. What are these rules (provide a short definition for each as well)?

10)What is the difference between a benign tumor and a malignant tumor?

indigohedgehog242

Part A:

In prokaryotes and eukaryotes cell reproduction is similar in that it requires some kind of signal to proceed, DNA replication, careful separation of the DNA into two equal portions, and division of the cytoplasm. How is cell reproduction different in prokaryotes and eukaryotes?

Select one:

a. In a eukaryotic organism, the signals for cell division are usually not related to the environment but to the function of the entire organism.

b. Eukaryotic cells constantly divide whenever environmental conditions are adequate and the cells are large enough.

c. The linear chromosomes in prokaryotes are constantly being updated.

d. Prokaryotic cell division requires cytokinesis before mitosis because of their small size.

e. The sexual phase of most prokaryotes (bacteria) is essential to the rapid cell division required for infection.

Part B:

What does the name Cyclin Dependent Kinase stand for?

Select one:

a. A protein important to the cell cycle that is dependent on DNA synthesis.

b. An enzyme that cuts DNA so that chromosomes can segregate.

c. An enzyme that phosphorylates other proteins using ATP only when the protein Cyclin is bound to the enzyme.

d. An enzyme that rolls along microtubules dragging a vesicle.

e. An enzyme that connects chromosomes to the spindle fiber.

Part C:

The Cell Cycle is divided into Mitosis, Cytokinesis, and Interphase. Mitosis can be ordered into the following phases:

Select one:

a. Prophase/Prometaphase/Metaphase/Anaphase/Telophase

b. Anaphase/Prometaphase/Metaphase/Prophase/Telophase

c. Metaphase/Anaphase/Telophase/Prophase/Prometaphase

d. Telophase/Prophase/Prometaphase/Metaphase/Anaphase

e. Anaphase/Telophase/Prophase/Prometaphase/Metaphase

Part D:

The Cell Cycle is divided into Mitosis, Cytokinesis, and Interphase. Interphase can be ordered into the following phases:

Select one:

a. S/G1/G2

b. G2/G1/S

c. G1/S/G2

d. G2/S/G1

e. G1/G2/S

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BIOL 112 Lecture Notes - Lecture 13: Spindle Apparatus, Homologous Chromosome, Kinetochore

BIOL 112 Full Course Notes

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