BIOL 200 Lecture Notes - Lecture 11: Exon Shuffling, Orf 2, Orf Eins
Document Summary
Yin & yang situation where transposon activity is sometimes beneficial although mostly, bad. Corn: usually within one kernel, all cells have same genotype. But for variegated: yellow part is where the pigment gene is disrupted by transposon (so purple color cannot be expressed) This disruption is passed down thru the generations, since it happened in germline cells (in contrast, the corn disruption happened in somatic cells) In drosophila: p-element insertion into s6 kinase gene affects body size. In rice: tos17 insertion into pish gene leads to fungal infection susceptibility. Disrupts the gene such that the protein which opposes the fungus isn"t produced anymore. Gene duplication is a result of unequal crossing over (recombination) Many proteins in our body are modular structures. Exon shuffling: mediated by recombination b/w mobile elements. Usually deleterious: newly recombined genes don"t produce functional proteins. Transposase excision (removes dna transposon from original gene) --> transposase insertion (inserts transposon into target gene)
