BIOL 200 Lecture 27: Lecture 27- Protein Folding and Quality Control

• School: McGill University
• Department: Biology
• Course: BIOL 200
• Professor: Thomas E Bureau

Document Summary

Summary of protein translation mrna in the cytoplasm polypeptide. Interactions with the small subunit (that require specific eukaryotic initiation factors, initiator trna) Important to note that these events are like contingencies solidified by the hydrolysis of gtp by these critical factors. Once you hydrolyze gtp to gdp, you don"t go back. You"re committed to the next step in these series of contingencies. Energy from gtp hydrolysis promotes a conformational change in the ribosome. Ef1alpha is very important for bringing in trnas into the a site in its gtp bound form. If you have a very long poly a tail then you are more efficiently translated! Recall that in the cell there are all these different mechanisms that chew away at the. If you chew off all the as at the 3" end, then there is not much room for the pabp to interact with.