BIOL 200 Lecture Notes - Unfolded Protein Response, Peroxisome, Cannibalism
6 Apr 2012
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Protein folding and quality control: mrnas are inherently the most stable type of rna because of their 5" cap and 3" poly (a) tail. This is because there are 3 degradation pathways through which and mrna molecule can be degraded: A decapping pathway involves exonucleic digestion of the 5" cap, following by exonucleic decay of the entire molecule. A deadenylation pathway involves exonucleic shortening of the poly (a) tail followed by exonucleic decay. An endonucleic pathway involved endonucleic cleavage of the mrna, followed by digestion by exonucleases. Therefore, mrnas with longer poly (a) tails tend to last longer than mrnas with shorter ones. One method of protein quality control involves the first round of translation, called the pioneering round. Normally, all mrna binding proteins are removed during mrna remodelling, leaving only the ribosome and other proteins required for translation (such as pabpi if needed)
