BIOL 200 Lecture Notes - Lecture 1: Dna Replication, Nucleoplasm, Cytosol
7 Jun 2016
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Document Summary
Cytosol compartmentalized away from the nucleus and nucleoplasm. Dna replication and dna transcription occur in nucleus. Give rise to products that are (in case of transcription) exported to cytosol and exposed to translational machinery which allows translation and protein synthesis to occur. In transcription coding sequence contains genomic information for future survival of cell in strand of dna. Dna encodes the information that is required for the synthesis of proteins. In that process you take 4 base pair dna sequence and transcribe it to a ribonucleotides sequence mrna. Transcription: dna helix unwinds, one strand associates with rna polymerase, rna polymerase is a catalytic multisubunit complex, rna polymerase polymerizises rntps based on the information encoded in the dna molecule, results in complimentary strand of rna. Pre-mrna synthesises from discrete units known as genes. Pre-mrna undergoes process called rna processing to remove noncoding sequences within the rna. After rna processing occurs you have formation of mrna (has 5" cap, 3" end processing)
