BIOL 200 Lecture Notes - Lecture 15: Cd154, Lymph Node, Cd28

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7 Jun 2016

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You are able to make mutilple billions of antibodies. Programmed into the t cells in the thymus. Programmed into b cells in the bone marrow. No antigenic configuration for which you are not prepared to react to when you are born. You don"t learn anything about immune reactivity after you are born. Dendritic cell is sitting between t cells and b cells: 2 different molecules come from t cells. Programmed in thymus to react only to specific epitope on antigen. Molecules synthesised by t cell surface if the t cell is sure. Binds to b7 on surface of dendritic cell (co-receptor) If that doesn"t happen there is not immune response: animal becomes tolerant of that peptide forever, ctla4 another molecule produced by t cell to bind b7. Once b7 and cd28 molecules stop interacting the immune response stops. If response keeps up the immune response it involutes: there are times when we don"t want antibody response to stop.

Related Questions

Question 4 (9 points):

To study T cell development, and self-restriction of T cells, you decide to perform some experiments. You obtain four mouse strains: B, B-MCC, K, and K-MCC. B strain mice express MHC molecules of the b haplotype (e.g. H-2K^b, H-2D^b, I-A^b) while K mice express MHC of the k haplotypes (e.g. H-2K^k, H-2D^k, I-A^k). The strains are otherwise genetically identical. B-MCC and K-MCC are identical to the B and K strains (respectively) excepts that contain a transgene encoding the antigen Moth Cytochrome which is not present in normal mice. MCC is produced as both a secreted and cytoplasmic protein and it is expressed by dendritic cells and thymic epithelial cells. You lethally irradiate groups of mice from all four strains and perform all possible bone marrow transfers among the mice. In other words, the BM of each strain is transplanted into mice of each strain, producing 16 different combinations of donor BM and recipient strain. You now take T cells from the lymph nodes of each of the 16 types of transplanted mice and test their ability to proliferate in response to MCC-presenting B cells that express only class II MHC molecule, I-A^k. Fill out the chart below by indicated which mice will have T cells that respond. Use (+) to indicated proliferation and NR to indicate a lack of proliferation. In addition, for the mice labelled a-e give a brief explanation for your answer. Include the mechanism of T cell selection experienced in thymus (positive selection, negative selection, or neglect) and the cells involved in selection (thymic epithelial cels, BM-derived APCs, or both).

Table (4 points, 0.25 points per box)

Recipient Strain Â®

BM Donor	B	B-MCC	K	K-MCC
B			c.
B-MCC			d.
K	a.	b.	e.
K-MCC

1 point for each explanation

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BIOL 200 Lecture Notes - Lecture 15: Cd154, Lymph Node, Cd28

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