BIOL 200 Lecture Notes - Lecture 14: Cpeb, Polyadenylation, Eif4E
7 Jun 2016
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Document Summary
Cytoplasmic mechanisms of post translational control of gene expression. You have rna in the cytoplasm, talking about controlling expression of mrna from cytoplasmic point of view. Binding through eif4e and poly a adenylation factors making a loop concentrated: rna degradation, mrna localization, translation regulation, translationally inactive. In unfertilized egg, many mrnas are stored with short poly a tails and transitionally silent. Mother pumps out rnas that she doesn"t want translated until the rna is ready to go. Suppressed translation of those rnas until embryo ready for next stage of development. You have initiation factors structured on initiation factor that links the to the poly a tail. Many rnas are stored with a short poly a tail. Things you care about don"t have poly a tail. Things that you don"t care about do have poly a tail. After egg fertilization, the mrnas are activated by cytoplasmic polyadenylation. Requires a u-rich signal (called cpe) in addition to the.
