BIOL 200 Lecture Notes - Lecture 10: Alternative Splicing, Spliceosome, Polyadenylation
7 Jun 2016
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Document Summary
Sxl regulates tra pre-mrna splicing by the same mechanism. Tra regulates the splicing of dsx pre-mrna: only females have tra. It forms a complex with rbp1 and tra2, directs splicing of exon 3 and exon 4, promotes cleavage and polyadenylation at an alternative poly(a) site at the 3" end of exon 4: males have no tra. Exon 4 is skipped, exon 3 is spliced to exon5, polyadenylation occurs downstream of exon 6: different forms of dsx transcriptional repressor are produced in male and female embryos. Alternative splicing and organ regulation - cochlea in. Extensive alternative splicing leads to the production of many isoforms of slo protein that can respond to different sound frequencies. In cochlea have an apical basal distribution of hair cells that have been hardwired through their expression of transmembrane domain protein that is a calcium triggered potassium channel. At apical end, hair cells will recognize frequencies at 50 hz.
