BIOL 200 Lecture Notes - Lecture 24: Nuclear Localization Sequence, Nuclear Export Signal, Nuclear Pore
Document Summary
So mrna is processed, then what: moves from nucleus to cytoplasm. Nuclear pore complexes resemble baskets, and are the sites of nucleocytoplasmic transport: will let small molecules through nuclear pores, large proteins and macromolecular complexes must be regulated in order to pass through. The nuclear pore complex is a highly ordered structure: individual elements are made up of speci c proteins which play critical roles in ensuring who and how things get through. Transport through the npc depends on reversible hydrophobic interaction: fg nucleoporins are hydrophobic. Nucleoporins are all the proteins that contribute to the formation of the structure. Fg nucleoporins are critical for the movement of a number of complexes: have fg-repeats (confer a hydrophobicity to the protein) Transporters take advantage of this hydrophobic domain in order to take things through nuclear pore complex - interact with fg-repeats on fg nucleoporins: hydrophobic interactions allow movement across barrier.
