BIOL 200 Lecture Notes - Lecture 34: Dodon, Alternative Splicing, Organelle
Document Summary
Phosphorylation of the ctd of large subunit of rna pol ii occurs. Upo(cid:374) the i(cid:374)itiatio(cid:374) of t(cid:396)a(cid:374)s(cid:272)(cid:396)iptio(cid:374) the (cid:1009)" e(cid:374)d of the e(cid:373)e(cid:396)gi(cid:374)g p(cid:396)e-mrna is modified (cid:120) once initiated and start to form pre-mrna, as it emerges from the transcription bubble, it needs to (cid:120) be capped. It"s (cid:373)odified so that enzymes that deg(cid:396)ade rnas (cid:449)o(cid:374)"t (cid:272)he(cid:449) it up (cid:120) cap is put on by an enzyme that recognizes the phosphorylation of. Maturation of nascent transcripts must occur to form functional mrnas (cid:120) cappi(cid:374)g e(cid:374)z(cid:455)(cid:373)e (cid:449)ill (cid:396)e(cid:272)og(cid:374)ize (cid:1009)" end of pre-mrna: precursor mrnas (pre-mrna) a(cid:396)e (cid:373)odified at thei(cid:396) (cid:1009)" e(cid:374)d (cid:120) I(cid:374) a(cid:374)i(cid:373)al (cid:272)ells a(cid:374)d i(cid:374) highe(cid:396) pla(cid:374)ts, the (cid:1006)" h(cid:455)d(cid:396)o(cid:454)(cid:455)l of the (cid:396)i(cid:271)ose g(cid:396)oup of the fi(cid:396)st (cid:271)ase is (cid:373)eth(cid:455)lated. In vertebrates the second base is also methylated (cid:120) (cid:120) (cid:120) addition of the cap protects the pre-mrna from enzymatic degradation, while facilitating nuclear export and recognition by translation initiation factors.
