BIOL 201 Lecture Notes - Lecture 17: Conformational Change, Atp Hydrolysis, Post-Translational Modification
Document Summary
Frogs can make themselves lighter and darker according to their mating needs, by spreading their organelles out or moving them close. The dark black dot moving to the right in the movie is an organelle, or a subcellular structure, moving back and forth along the axon. Kinesins were first purified from the giant squid axon. A motor protein, by definition, converts chemical energy to. Light chain: part of how cargo is selected. The big blobs down below are head domains. They walk for about 1 m before they dissociate. We have a brain to help us walk. Adp-state is a weak-affinity state, when it doesn"t care for the microtubule. Your trailing head (foot) is free, your forward head is bound. Now your forward foot binds atp, causing a conformational change. The forward shoe cannot bind atp unless the grey shoe behind hydrolyzed atp. When kinesin has both feet down, there"s a strain put on the neck-linkers.
