BIOL 201 Lecture Notes - Lecture 18: Squid Giant Axon, Secretion, Melanosome
11 Apr 2018
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Exam viewings next week for multiple choice questions. Short answer marking rubric is going to be up on mycourses to. May be a lot of feedback from tas. Long range transport is driven by motor proteins: example of baggage: Secretory vesicles: cells can regulate transport. Make pigment-containing organelles (melanosome) making melanin: high camp leads to dispersed melanin in melanosomes, low camp leads to melanosome aggregation. Lighter : transport can be activated or inhibited by signaling molecules. Squid giant axon is useful for imaging of transport: some molecule moves the substances down the axon, squish the axon and extract molecules. Isolate protein in squid axoplasm responsible for transport kinesin motor protein. Motor protein traveling towards microtubule + end (in axons, responsible for anterograde. Kinesin transports vesicular cargo: vesicle is bound to kinesin receptor, analogy between catalytic core of myocin and kinesin (head domain) Receptor recognises kinesin tail domain and walks along the microtubule. Motif is conserved (alpha helices surrounding beta sheets)
