BIOL 201 Lecture Notes - Lecture 5: Lynn Margulis, Superoxide Dismutase, Wild Type
Document Summary
Places where the inhibitors bind and where the activators bind are separate from the active site itself. Pfk is inhibited by its products, atp and citrate. Mutation caused the molecule to be no longer inhibited by the product. Atp starts binding to separate allosteric inhibitory site. Pfk is activated directly by amp and indirectly by excess fructose-6-phosphate. Aerobic respiration as the putative drive for endosymbiosis. Mitochondria make their own ribosomes, segregate their own dna, etc. The question of the origin of the eukaryotic cell and its organelles is reexamined. Aerobic proto-eukaryote that enlarged and engulfed its respiratory surfaces. Mitochondria and nuclear genome make a copy each. Mitochondrial proteins are built from a combination of nuclear and mt dna. The petite mutation in yeast is a model for mt dna inheritance. Petit cells occur by chance due to the random segregation of mtdna. Propagate as a petit cell until it mates back with healthy cell again.
