BIOL 201 Lecture Notes - Lecture 7: Inner Membrane, Pink1, Mitochondrial Matrix
31 Jan 2018
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Document Summary
Although mitochondria are mainly known for producing atp, they participate in other metabolic pathways: house the first rate-limiting step of heme synthesis, provide small molecules useful in larger biosynthetic pathways, such as: These molecules are used, for example, to make acetyl coa, nadph, glutathione, purines, fatty acids and cholesterol. Mutations in mitochondria affect 1 in 5000 live births and usually cause disease. Mitochondria have two distinct membranes: outer membrane. Defines outer perimeter of mitochondrion, contains the mitochondrion: flat, lines the inner surface of the outer membrane. Inner membrane area is higher than outer membrane area. In some cells (ex: heart muscle cells), the total surface of all mitochondrial membranes can be over 17 times the surface of the plasma membrane. Crista junction cristae organising system (micos) protein complex: junction between cristae and the boundary membrane, highly incurved: curve is set up by mitochondrial contact site and.
