BIOL 201 Lecture Notes - Lecture 8: Hydroxy Group, Pyruvate Dehydrogenase, Gluconeogenesis
26 Jan 2016
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Tca cycle as a source of biosynthetic precursor molecules. Fatty acids are long aliphatic chains that have a carboxylate group at one end. They can be saturated or unsaturated (with double bonds), e. g. palmitic acid. Free fatty acids don"t exist at high levels in the cell. Fatty acids fatty acyl coa acetyl coa tca cycle. Coa is a carrier of activated acyl groups. Fatty acid oxidation can occur in mitochondria or peroxisomes. Pathways similar in both compartments: electrons are dealt with differently in the two organelles. Products are facoa 2c + acetyl coa. Biol 201: 2 carbons shorter than the long aliphatic chain. In mitochondria, fadh2, nadh oxidized by respiratory chain: adp + pi atp. In peroxisome fadh2 reduces o2 to h2o2, nadh acetyl coa exported. Introduce a double bond and convert fad to. When gluconeogenesis and fatty oxidation occur simultaneously, insufficient oaa to react with acetyl coa produced. Acetyl coa molecules react with one another.
