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Lecture

BIOL 202 Lecture Notes - Reductionism, International Hapmap Project, Haplotype


Department
Biology (Sci)
Course Code
BIOL 202
Professor
Daniel Schoen

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BIOL 202 - Basic Genetics
Lecture #1 - Introduction
Reading: Ch. 1 (p.1-25)
Administrative stuff
Conferences begin on Jan. 21st - 1.5 hours/week (see schedule on myCourses)
Textbook: Introduction to Genetic Analysis 10th ed.
Midterm Exam: Thursday 21 February 6-8pm (will be 1.5 hours long)
Midterm Exam (all multiple choice) - 35% (Lectures 1-14)
Final (multiple choice and short answer) - 65% (Lectures 15-37)
Overview of Genetics
Biologists are interested in how organisms function. They ask
questions about biological function.
Biologists use a reductionist approach.
A geneticist searches for mutations (in natural populations or
a mutation that they may create in some way with chemicals
or with radiation). These mutations disrupt function.
Geneticists learn about function by studying mutations. You
can learn something by comparing the mutant form of the
organism and non-mutant organism and through this you can
infer some things - this is called genetic dissection.
Lets say youʼre interesting in curing a genetic disease, if you
know what that gene does, you might be able to develop a
therapy based on substituting for individuals who have a
mutation that causes that disease.
Molecular biology gave us the tools for geneticists to manipulate the code and allowed cell
biology/biochemistry to communicate with genetics.
Approaches in Genetics
1. Forward Genetics
We look for natural
mutations. Make crosses
between phenotypes that
differ and look at offspring
ratios. We look for the
genetic control of that trait -
does it look like its controlled
by a single gene? Does it
look like its controlled by
many genes? Does it even
have a genetic basis? So in
a nutshell: make crosses
between genes, note
offspring ratio and infer the
molecular and developmental
differences which could lead you to identifying the DNA sequence. Weʼre going forward from
the different forms (form the mutations) down to the DNA sequences.
Sarah Margareta Ibrahim"Monday, January 7th 2013
"1
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