BIOL 202 Lecture Notes - Lecture 17: Chromosomal Rearrangement, Gametogenesis, Chromosome

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redclam140

24 May 2021

School

McGill University

Department

Biology

Course

BIOL 202

Professor

Western, Dankort, Nilson, Hipfner and Schoen

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Document Summary

50% of the produced individual"s gametes are trisomic (2n+1) 50% of the produced individual"s gametes are monosomic (2n 1) produces an individual that is mosaic for genetic conditions and expressing certain phenotypes consequences of nondisjunction: at meiosis i: 2 gametes have extra chromosomal copy: no normal gametes are produced, 4 aneuploid gametes are produced, have an extra copy of the paternal chromosome, have an extra copy of the maternal chromosome. 2 gametes have no chromosomes (less than normal) at meiosis ii: 50% (2/4) are normal gametes, 50% (2/4) are aneuploid gametes: 1 gamete has an extra chromosome (from the same parent) Cri-du-chat syndrome: deletion on chromosome 5: missing a large section of the short arm of the chromosome (15. 2 to 15. 3): significance of 5p 15. 2 5p 15. 3 region: Ii: 1 copy of the 5p region is not enough to produce normal function. 5p deleted region genes are vital for development.

Related Questions

-Complete the following sentences: metaphase of mitosis, prophase II of meiosis, crossing over, anaphase I of meiosis, variable, random fertilization, identical, random orientation, metaphase I of meiosis, prophase I of meiosis, metaphase II of meiosis, reduction division

Two processes that occur during meiosis produce genetically ____________ cells.

In a process called ____________ , paired homologous chromosomes align randomly at the cell equator. This occurs during this stage of cell division: ____________ .

In a process called ____________ , genetic material is exchanged between homologous chromosomes. This occurs during this stage of cell division: ____________ .

-Complete the following paragraph to describe nondisjunction and the resulting effects on chromosome number.

words: euploidy, primary nondisjunction, nomal, nondisjunction, secondary nondisjunction, homologous chromosomes, abnormal, trisomy, monosomy, sister chromatids, aneuploid

1.During meiosis I, ____________ separate and move towards opposite ends of the poles.

2.During meiosis II, ____________ separate and move towards opposite ends of the poles.

3.During meiosis I, if both members of a homologous pair go into the same daughter cell, ____________ is said to occur and no normal gametes are produced.

4.During meiosis II, if the sister chromatids fail to separate and both daughter chromosomes go into the same gamete, ____________ is said to occur. Half the gametes are aneuploid while the other half are euploid.

5.If an egg that contains 24 chromosomes instead of 23 chromosomes is fertilized by a normal sperm, ____________ is said to have occurred.

6.If an egg that contains 22 chromosomes instead of 23 chromosomes is fertilized by a normal sperm, ____________ is said to have occurred.

Nondisjuction is a cell division error in which either homologous chromosomes or sister chromatids fail to separate and thus do not migrate to opposite poles. It is responsible for conditions such as monosomy (one member of a chromosome pair is missing) and trisomy (three copies of a chromosome is present rather than two).

Nondisjunction can occur during the first or second meiotic division.

Part A- Jill is heterozygous for gene A and is going to have a child with Jack, who is homozygous recessive for gene A.

Which of the following offspring genotypes could result from fertilization of a normal haploid sperm with an egg that had undergone nondisjunction in meiosis I?
Check all that apply.

1)AAa

2)Aaa

3)aaa

4)Aa

5)aa

6)a

I put AAa, Aaa, Aa, but it was not correct

Part B-

Which of the following offspring genotypes could result from fertilization of a normal haploid sperm with an oocyte that had undergone nondisjunction in meiosis II?

Check all that apply.

1)AAa

2)Aaa

3)aaa

4)Aa

5)aa

6)a

Part E-

If Jack and Jill have a child with an aaa genotype, during which meiotic division, and in which parent, could nondisjunction have occurred?

Check all that apply.

1) Meiosis I in the mother

2 Meiosis II in the mother

3) Meiosis I in the father

4) Meiosis II in the father

The answer is not Meisis I in the mother

Determine whether the following applies to mitosis, meiosis, orboth; also identify the specific stage of cell division thatapplies (e.g. mitosis prophase, meiosis anaphase II, etc)

1) chromosomes pairs line up across the center of the cell

2) sister chromatids seperate

3) spindle fibers separate homologous chromosomes

4) 4 haploid daughter cells are produced

5) a cell 1st undergoes DNA replication

6) chromosomes line up single file across the middle of thecell

7) sister chromatids separate from each other

8) 2 haploid daughter cells form

9) the nuclear membrane re forms

10) spindle fibers attach to pairs of homologous chromosomes

11) the nuclear membrane begins to dissolve

12) centrosomes duplicate

13) synapsis and crossing over occurs

14) 2 diploid daughter cells form

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BIOL 202 Lecture Notes - Lecture 17: Chromosomal Rearrangement, Gametogenesis, Chromosome

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