BIOL 202 Lecture Notes - Lecture 15: Spliceosome, Crispr, Ribosome
11 Mar 2015
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Document Summary
Lecture 15: key discoveries in the physical basis of heredity, variability in genome size, using genome structure to understand function. Pangenesis: mechanism that cells in body produce particles that travel to germ line that are then transmitted to next generation blended inheritance. In the late 1800s, many microscopists observed chromosomes. Wihelm roux proposed that they were the physical substrate for trait inheritance in 1880. A correct number of chromosomes is required for development (1901) **proteins** varied types, enzymatically active: a boring, repetitive polymer called deoxyribonucleic acid. Non-virulent r strain has been transformed into a virulent strain by something from the heat killed s- strain. Used dnase and protease to find that dna was the transforming principle. Used radioactivity to label strains: infection 2. First good structural data of dna helical structure based on x-ray diffraction of crystalline dna. 1. 9 meters of dna must be packaged in a cell nucleus ~ 10 microns in diameter.
