BIOL 300 Lecture Notes - Lecture 29: Raf Kinase, Threonine, Proteoglycan
16 Dec 2017
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Common property of all kinases = they dimerize : the ligand is typically a protein, much larger than the small molecules-ligands for gpcrs, gprc singling is fast vs. kinase receptors are much slower. > glycosaminoglycan chain of the proteoglycan binds to fgf (fibroblast growth factor). The transmembrane heparan sulphate proteoglycan contains amino acids to which sugar chains are attached, which are very important in giving the proteoglycan its integrity. Ephrins: transmembrane ligands found in the signaling cells > they are recognized by the eph receptors on the target cell, in a very restricted and limited manner. Ligand-bound activated receptor cross-phosphorylates tyrosine residues in the cytoplasmic tail. General structure of rtks (lodish, p. 734: the cytosolic domain of rtks contains an intrinsic protein tyrosine kinase catalytic site, in the absence of ligand (step. ), rtks generally exist as monomers with poorly active kinases. The activated kinase then phosphorylates several tyrosine residues in the receptor"s cytosolic domain (step.
