BIOL 300 Lecture Notes - Lecture 15: Exon, Alternative Splicing, Stem-Loop
5 Mar 2018
School
Department
Course
Professor
Document Summary
Rna editing: rna-editing: alterations of rna sequences such as insertion, deletion and modification, which occur post-transcriptionally (excludes the common slicing events), wide spread in mitochondria of protozoan and chloroplasts of plants. In higher eukaryote, it is much rarer but does exist. It inserts different number of as into its transcribed rna. It codes its own polymerase which will transcribe the rna template; coded by l. It uses a stretch of u to insert as, however the number of as it will insert in this position is different (more as than the number of a that are coded by the template. Apolopoprotein b rna editing: apob proteins bind to lipid and form large lipoprotein complexes (important for intake and transport of cholesterol). It requires another protein for its target specificity: acf (apobec1 complementation factor: acf recognizes specific rna sequences, mooring sequence, downstream of the edited c, it works as a homodimer, the whole thing is called the editosome.
